Mutant snakes survived a terrorist attack on a government laboratory, and they now threaten the town of Santa Mira Springs, California. Seismic activity has brought snakes to the surface, where residents are being bitten. Victims can transmit the virus to healthy persons. The military puts the town under quarantine. Local physicians try to control the epidemic, while the military is primarily concerned with keeping the virus a secret.
After the death of his estranged mother, a misogynistic womanizer returns home to find that his ex-girlfriend had been his mother's secret lesbian lover.
In an apocalyptical future, the world is completely destroyed and ruled by the tyrannical Stryker. He controls the unique source of food and uses young women as slaves to explore the mines in the Hell Mountain. When he abducts Shira, her lover Kal meets with the last professor on earth, Garrett, who helps him to rescue Shira.