Twentysomething Brooklynites Mara and Jo have been close friends since middle school. Gradually, it becomes apparent that the increasingly unstable Jo has troubles that may be the result of substance abuse, or an even deeper problem. Over the course of a decade, the more stable Mara tries to help.
In 1979, an Indian family moves to America with hopes of living the American Dream. While their 10-year-old boy Smith falls head-over-heels for the girl next door, his desire to become a "good old boy" propels him further away from his family's ideals than ever before.