Byron Turner, a 15-year-old runaway from the Eatondale Orphan Asylum, receives a ride into the rural Missouri town of Delphi with rich land-owner Tobias Brown.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
The "one desire" of ex-gambler Clint Saunders and bar woman Tacey Cromwell is to escape their shady former lives and settle down to respectability. With Clint's younger brother and an orphaned girl in tow, the couple moves to a Colorado mining town where their love is tested by Judith Watrous, daughter of the town banker, who has her sights on Clint.
