In 1920s Ireland young doctor Damien O'Donovan prepares to depart for a new job in a London hospital. As he says his goodbyes at a friend's farm, British Black and Tans arrive, and a young man is killed. Damien joins his brother Teddy in the Irish Republican Army, but political events are soon set in motion that tear the brothers apart.
In the seventeenth film in the series, in 1918, a top-secret mission for French Intelligence brings Indy to Istanbul. Exploring the city's dark and dangerous streets, he is thrust into a web of betrayal and murder when he discovers a vile Turkish plot to assassinate French espionage agents. Evil of a more enduring kind awaits him in Transylvania, where he engages in mortal combat with bloodthirsty Vlad the Impaler and his horrific army of the living dead. With his very life at stake, Indy must garner all his strength and wits in order to defeat the fiend and save mankind.