A conservative lawyer named Diane takes her two teenage children Jake and Zoe to meet their estranged, hippie grandmother in Woodstock after her husband asks for a divorce.
New Yorkers Paul and Meryl Morgan seem to have it all -- except that their marriage is crumbling around them. But their romantic woes are small compared to the trouble they find themselves in after witnessing a murder. To protect them from an assassin, federal agents whisk away Paul and Meryl to a small town in Wyoming, where their marriage will crash and burn, or their passion will reignite.
Whatever Works explores the relationship between a crotchety misanthrope, Boris and a naïve, impressionable young runaway from the south, Melody. When Melody's uptight parents arrive in New York to rescue her, they are quickly drawn into wildly unexpected romantic entanglements. Everyone discovers that finding love is just a combination of lucky chance and appreciating the value of "whatever works."