A long-distance trucker, dressed like a sea captain, aimlessly sails the American highways in his 18 wheeler mumbling manic, southern accented non sequiturs; carnivalizing roadside stops and happenstance towns while out-weirding cops and weigh stations with his new cryptic, over-coated hitchhiker buddy.
Schoolteacher Bertram Cates is arrested for teaching his students Darwin's theory of evolution. The case receives national attention and one of the newspaper reporters, E.K. Hornbeck, arranges to bring in renowned defense attorney and atheist Henry Drummond to defend Cates. The prosecutor, Matthew Brady is a former presidential candidate, famous evangelist, and old adversary of Drummond.