Professional killer Bus Crow is hired by cattlemen to eliminate squatters. When Marshal Sam Rochelle is sent to investigate, saloon owner Hallie has to be a reluctant witness.
Naive Ezekial Cobb, brought up by his missionary father in China returns to America to seek a wife. Corrupt politicians enlist him to run for mayor as a dummy candidate with no chance of winning. Their plan backfires as he wins and embarks upon a reform crusade.
In the 1860s, Mary Marlowe defies her father's wishes to marry a British lord and runs away with clerk John Carlton as he heads West to make his fortune. Mary and John endure the difficult journey and settle into a small cabin, then face the hostilities of a cattle rustling gang, as well as the tragic loss of their only son. With Mary's help, John defeats the gang, which propels him to political power that, over the years, gradually erodes the once-happy marriage.