A. J. Niles is the author of a series of 'Bachelor Books'. These books describe the romantic life of a bachelor in various cities of the world. But when he runs into trouble with the I.R.S. for back taxes, he needs to write another book fast, to pay them. His publisher decides a book about life in the American suburbs would be a hit and settles him into Paradise Village. One bachelor plus lonely housewives equals many angry husbands.
Alan Mitchell returns to New York to work for his father Walter, the owner of a fashion house that designs and manufactures dresses. To stay non-union, Walter has hired Artie Ravidge, a hood who uses strong-arm tactics to keep the employees in line.
Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.
An electric shock enables Satch to predict numbers, so the Bowery Boys are off to Las Vegas to win enough money at the roulette wheels to let their landlady buy an apartment building. Witnessing his winning streak, some gangsters decide to move in and find out his "system" for beating the odds.