Toxie finds he has nothing to do as a superhero, as he has ridden his city of evil. So he decides to go to work for a major corporation, which he discovers may be the evilest of all his adversaries.
The Toxic Avenger is lured to Tokyo, Japan by the evil corporation Apocalypse Inc. So while the Toxic Avenger is fighting crime in Tokyo, Apocalypse Inc. spread evil in Tromaville.
The film documents the beginning of the punk rock movement in New York City at CBGB's, a punk night club, and the lifestyle that revolves around this scene. It presents a sometimes shocking look at the attitudes and motivations behind the movement through interviews with outspoken club-goers and band members of the Ramones, Richard Hell and the Voidoids, and the Dead Boys.