Office temp Charlotte Cantilini thinks she's found Mr. Right when she starts dating gorgeous surgeon Dr. Kevin Fields. But there's a problem standing in the way of everlasting bliss: Kevin's overbearing and controlling mother, Viola. Fearing she'll lose her son's affections forever, Viola decides to break up the happy couple by becoming the world's worst mother-in-law.
After a small misunderstanding aboard an airplane escalates out of control, timid businessman Dave Buznik is ordered by the court to undergo anger management therapy at the hands of specialist Dr. Buddy Rydell. But when Buddy steps up his aggressive treatment by moving in, Dave goes from mild to wild as the unorthodox treatment wreaks havoc with his life.
Three longtime pals live in San Francisco: Darin is married to Natalie, but their family life is too still and Darin is not happy about it, Matt is ladies' magnet but tired of it, trying to get something stable from his relationships, and goofy Kevin doesn't have any success with women at all. Darin starts an affair with his friend's wife Maxine and Matt falls deeply in love with a woman he has seen once.