Eight months after the death of his wife, Frank Goode looks forward to a reunion with his four adult children. When all of them cancel their visits at the last minute, Frank, against the advice of his doctor, sets out on a road trip to reconnect with his offspring. As he visits each one in turn, Frank finds that his children's lives are not quite as picture-perfect as they've made them out to be.
Andrew returns to his hometown for the funeral of his mother, a journey that reconnects him with past friends. The trip coincides with his decision to stop taking his powerful antidepressants. A chance meeting with Sam - a girl also suffering from various maladies - opens up the possibility of rekindling emotional attachments, confronting his psychologist father, and perhaps beginning a new life.
The gay son of a conservative senator who is also the poster boy for his father's re-election unknowingly befriends a gay activist bent on destroying the hypocritical campaign.
A week in the lives of a group of models, photographers, agents, reporters, publicists and other characters during a wild modeling show in New York City.