Rhonda, a big-haired bankteller from Brooklyn, encounters Travis, naked, suicidal and about to jump off the Brooklyn Bridge. Mistaking him for her perfect man, she stalks him all the way to Danton, Texas. An alliance, and eventually true friendship, is formed between this extremely odd couple as they embark upon a 'treasure hunt' - with clues provided from beyond the grave.
Herbert West once again revives the dead. This time, he brings Dan's ex-girlfriend's heart back inside a 'perfect' body. Dr. Hill returns as the evil nemesis who lost his head.