록키의 후계자인 크리드는 월드 챔피언으로 권투계를 장악한 후 완벽한 삶을 살던 중 과거 친형제 같았던 데미안과 재회한다. 오랜 시간 감옥 생활을 마치고 나온 데미안은 그가 꿈꾸던 인생을 사는 크리드와 충돌하며 그의 모든 것을 빼앗으려 하고, 크리드는 이에 맞서 자신의 미래를 지키기 위한 일생일대의 대결을 준비하는데…
Wealthy big game hunter, Wilson Frields, funds an expedition going deep into the Florida Everglades to search for the Calusa: a lost tribe of Native Americans. When the team discover the gruesome remains of another expedition, Friels admits he is searching for the Calusa's Fountain of Youth and its guardian, a mythical and deadly beast. As they delve deeper into the Everglades, the bloodthirsty beast begins to stalk and kill members of the group and, in one struggle, their leader Brinson Thomas is injured and begins to metamorphose into a creature himself. His only hope: to drink from the waters of the Fountain. The terrible truth behind the Calusa must be discovered if any of them are going to get out of there alive!
