Chuffie & JD, both street dogs, meet a talking parrot named Emmo who has lost his owner. The dogs try and eat Emmo, but in order to save his life, the parrot promises them a new home with his owner, the wealthy Miss Lilly. The two dogs feel right at home at their new mansion, along with Miss Lilly's other pets (all strays): the beautiful Bella, the frisky Velvet, and the guard dog Sherman. Unfortuantely, it doesn't take long for Miss Lilly to "kick the bucket", and the dogs' future is in jeapordy, especially since Miss Lilly's scheaming niece & nephew, Ronnie & Hannie, have had their eyes on the estate for quite some time. When the will reveals that the pets are to inherit the estate (including the mansion and one million dollars!), the twins decide to take matters into their own hands to try and get what they think they deserve. It's up to JD, Chuffie, Emmo, Bella, Sherman, and Velvet to stop the twins.
1560년, 스페인 원정대는 아마존 강 기슭에 있다는 황금의 도시 엘도라도를 향해 모험을 나선다. 아무도 가보지 않은 전설의 땅으로 가는 길이 험난해지자 피사로 장군은 우루수아를 대장으로 임명하고, 40명의 선발대를 뗏목에 태워 강으로 먼저 보낸다. 원정대와 선발대가 약속한 사전 조사 기간은 일주일, 하지만 엘도라도에 대한 강한 정복욕에 사로잡힌 아귀레는 대장 우루수아를 가두고 반란을 일으킨다. 배고픔과 질병, 식인종들의 습격 속에서 작은 뗏목은 커다란 광기에 휩싸이는데...
