항상 약에 취해있고 추상적인 자기애를 가지고 있는 무기력한 사설 탐정 닥(호아킨 피닉스). 어느 날 그의 전 여자친구 샤스타(캐서린 워터스턴)가 갑작스레 사라진다. 실종되기 얼마 전 닥을 찾아왔던 샤스타는 그에게 뜬금없는 스토리를 이야기 해주며 도움을 청한다. 그녀와 현재 교제 중인 부동산 거물인 미키 울프맨의 부인과 그녀의 내연남이 울프맨을 납치하여 정신병원에 가두려는 음모를 꾸민다는 것이다. 샤스타의 말처럼 며칠 후 미키 울프맨은 사라지고, 그 직후 샤스타도 사라진 것. 일은 꼬이고, 이제 닥은 전 여자친구의 실종 사건을 둘러싼 미스터리를 해결하려 하는데...
Ashley is a journalist and does makeovers for a TV show. Her editor offers her the job of being the editor of a new fashion supplement, provided she does a makeover on a sports writer, who is an uncouth, loudmouthed, sexist slob.
Tweek City is a week in the life of Bill, a potentially closeted, half-Latino, small-time speed dealer in San Francisco's Mission District. Bill is stuck on an endless walk from one empty experience to the next. Only Bill's friend Jerm has the ability to connect and ground him in reality. When Jerm makes an ill-advised stage dive, Bill plunges into a downward spiral that takes him on a nocturnal journey through the streets of San Francisco and ultimately down to Los Angeles where he crashes his high school sweetheart's wedding. From his sleep-deprived, hallucinogenic state, Bill fails miserably in a desperate attempt to reconnect with his first and only love. With nowhere else to go, Bill jacks a car and ends up at the deserted drive-in theater of his childhood where he is forced to confront the ghosts that he had tried to leave behind.
