Set in the world of New York City's elite private kindergartens, The Best and the Brightest centers on a fresh-faced young couple, Samantha and Jeff, who have only recently moved into town. The comedy centers on their dawning realization of the lengths they must go to in order to get their five-year-old daughter into school.
Alex is a lonely accountant whose one act of rage results in her being sentenced to court-ordered therapy. There she meets Stella, the owner of a small extermination business who uses her car as a weapon, and Nikki, a dental technician with the face of an angel and the mind of a sociopath. Together these women form their own "silent revolution", wreaking havoc on the abusive men in their lives.
Norman Reedus stars as Harry Odum, a henpecked, 18-year-old momma's boy in Youngstown, Ohio, who -- with his violent temper -- impresses a local boss of the Jewish Mafia. Soon he's found his calling as a hit man alongside his crack addict partner Arnie Finklestein (Adrien Brody), and he discovers that his rage and complicated psychosis fuel his murderous abilities. Harry also falls for the organization's limping, Hungarian-born maid Iris (Elina Lowensohn), a romance complicated by Harry's Oedipal, sexual relationship with his domineering mother Kate (Deborah Harry).
Eliza D'Amico thinks her marriage to Louis is going great until she finds a mysterious love note to her husband. Concerned, she goes to her mother for advice. Eliza, her parents, her sister Jo, and Jo's boyfriend all pile into a station wagon to go to the city to confront Louis with the letter. On the way, the five explore their relations with each other and meet many interesting people.