The tiny independent duchy of Ferrara is located between Casare Borgia's Rome and Venice, and Borgia has plans to conquer Venice via Ferrara. He murders his sister's husband and makes it appear that Alfonso D'Este of Ferrara was behind the killing. To avenge herself against Ferrara and D'Este, Lucretia Borgia marries D'Este and intends to poison him. But...she falls in love with him.
On a Greek island during the 1912 war, several people are trapped by quarantine for the plague. If that isn't enough worry, one of the people—a superstitious old peasant—suspects a young woman of being a vampiric demon.