A corpse of a clown is found in a park. Detective Shirataka Amane of Musashino Higashi Police Station begins investigating with rookie detective Uzuka Shinsaku. They find a picture of the victim holding a balloon with the number 1 and the letters TTX on social media which indicates pufferfish poisoning. Shirataka intuitively suspects that this is an incriminating statement done by a serial killer, but Chief Investigator Fukukawa Saeko denies her. Detective Kusano Seiya and other personnel of MPD First Investigative Division join the investigation, then a second murder occurs. Shirataka recalls an unsolved kidnapping and murder case from two years ago that she still regrets.
Uma guerra no Japão faz com que o país seja devastado. Desesperado em restaurar a paz, Tokugawa Shogun, líder de um clã, ordena o assassinato de um comandante inimigo. Para realizar a tarefa é selecionada Azumi (Aya Ueto), uma jovem e bonita mulher que foi selecionada ao nascer, juntamente com outros 9 órfãos, para se tornar uma assassina.
Set many years after the end of the original Ultraman Tiga series, in which Daigo Madoka (human host of Ultraman Tiga) has a son with Rena, named Tsubasa Madoka. Tsubasa is a member of a new team, Neo Super GUTS, the successor to the original Super GUTS.
