Kos (13) is going through the most bizarre period in his life. His mother died a few years ago and his dad is having a heart attack. While Kos’ father is in the hospital, it looks like the hotel he is running will be a big mess. But Kos and his three sisters do not intend to let that happen. After the siblings find out that father is deep in financial problems, the hotel is threatened with closure. The children however come up with a solution: someone has to win the local beauty pageant, with a hefty cash prize attached.
Three teenagers appear to have a lot of fun on the children's oncology department on the fourth floor of a large hospital. Nick and Iwan both lost a leg as a result of bone cancer. For their friend Olivier, an amputation may be the next phase. The fourth of the bunch, Pepijn, is so ill and weak that he often stays in his room. Friendship and a deep desire to live keeps the guys mentally balanced. Their friendship changes when Gina arrives. Sickos is a humorous drama that deals with adolescence and chemotherapy.