Na década de 1970, em Nova York, as esposas de mafiosos irlandeses ficam no controle dos negócios em Hell's Kitchen depois que agentes do FBI prendem seus maridos. O grupo é liderado por três mulheres com temperamentos extremamente diferentes, mas que compartilham do mesmo objetivo: proteger a empresa de suas famílias, custe o que custar.
Photographer Barnard Jacobs is dying and Ashley, the woman he loves, won't admit her feelings for him. She's too wrapped up in her cocaine addiction and desire to find a wealthy husband. When fashionista Madeleine begs Barnard to call Ashley for drugs, a party develops. Madeline pairs off with a rich tech executive named Boccaccio. Barnard goes home, where Ashley, seeking peace and solitude, joins him. In flashback, Barnard recalls how his best friend Pickering hired him to take photos of women's eyes. He hired Ashley and the two forged a deep connection. Back in the present, Boccaccio and Madeleine do drugs and become removed from the world. As Barnard learns death is near, he reaches out to Ashley in a final attempt to save both of them.
