A Cameroonese police officer (Alphonse Beni) and a CIA agent (Richard Harrison) try to prevent the Pope from being assassinated by Italian terrorists during his African tour.
A crook masquerading as an Army Colonel in charge of gold shipments, replaces gold ingots with fakes. Spirito Santo is recruited to solve the case and make sure the gold gets through.
The authorities of Springfield ask Spirito Santo/Holy Ghost, which in turn will require the help of Diego of Habsburg and his colourful gang, to eliminate the threat constituted by an elusive masked bandit – and arms dealer – known as Solitario.
