Século XVII. Dois padres jesuítas portugueses, Sebastião Rodrigues (Andrew Garfield) e Francisco Garupe (Adam Driver), viajam até o Japão em uma época onde o catolicismo foi banido. À procura do mentor deles, padre Ferreira (Liam Neeson) os jesuítas enfrentam a violência e perseguição de um governo que deseja expurgar todas as influências externas.
Antonym is a slow-burning drama about human connection, told through the story of two women who come together to write a radio drama. Vain and self-centred Aya is forced to find a writing partner to work on the radio script she is developing. Heavily reluctant to collaborate, she partners shy co-worker Sachiko, who eagerly embraces the project. Peppered with coincidental occurrences and failed relationships, and powered by the friction and growing friendship between the women as they work on the script, Antonym is as much about the inevitability of human connection as it is about the necessity of it.
At a train station in the suburbs of Tokyo, an accident takes place causing death and injury. Tsuyoshi is at the scene and witnesses the death of a woman. Right before the accident occurred, Tsuyoshi took a photograph of the woman, who carried a gentle look. Later, Tsuyoshi learns the woman has a daughter named Kiriko. Tsuyoshi meets Kiriko.