Homens em todo o mundo, exceto os otakus virgens, se transformam em zumbis loucos por estupros que matam mulheres com seu sêmen tóxico. Alguns dos otakus sobreviventes se vingam das mulheres tridimensionais que os evitavam, caçando-os com bandos de zumbis domesticados. As mulheres do Japão devem se unir para sobreviver à praga de zumbis antes que tudo esteja perdido para sempre!
After radical feminism and the emasculation of men have caused the downfall of civilization, the few remaining humans live in various settlements with vast lawless lands in between. One such settlement is Amazon City, where men are seen as a mere food source and as a means to harvest the sperm from their chopped-off testicles. Since heterosexual procreation is now seen as the epitome of perversion, survival of this society relies on artifical insemination. With the previous lead scientist having been assassinated by the terrorists of the Love Liberation Army, Amazon City has recruited the talents of Dr. Maki Amamiya to take her place. Little did they know that Dr. Amamiya would show up in Amazon City with her husband in tow…
Aya, Nozomi, and Akane, who met in a chat room, playfully perform a séance called "Hitori Kakurenbo". During the game, Nozomi becomes possessed and dies a cruel death.