Baseado em uma história real. Arthur é um médico viúvo e ex-militar, que leva uma vida tranquila em um vilarejo nas montanhas da região do Daguestão, na Rússia.
Sasha e Petya são dois jovens músicos nos seus vinte e poucos anos que levam uma vida inconsequente na Moscou moderna: festas barulhentas, drogas, altos e baixos, relacionamentos instáveis e sentimentos conflituosos. Abandonados em mundo que valoriza amor, amizade, família e oportunidade, eles se sentem solitários, desconectados, cheios de dúvidas e com a sensação de que estão se corroendo por dentro. De repente, ocorre um evento em suas vidas que exige que ambos olhem para si mesmos com mais honestidade do que nunca.
Ivan, a successful oncologist who has created a cure for cancer, discovers suddenly that by an ironical twist of fate he is terminally ill. He realizes that he has one chance to correct the mistake he made a long time ago, and leaves his family to go to another city to the woman he loved all his life, hoping to spend the last night with her...
Following a brawl, Captain Ignat, who is traumatised by the death of his daughter, is ordered together with a regular soldier to find a deserter and bring him back via Moscow to stand before a military court. Although they locate the young soldier, their journey across the wintry moloch that is Moscow is slow and tortuous. Before long, the unlikely trio find themselves drawn into a chaotic maelstrom of violence, corruption, criminality, degradation and squalidness. In the face of the monstrous malaise and everyday horror of life in Russia, the gradual breakdown of the film’s anti-hero becomes a metaphor for Russian society.
In the year 2020, a group of wealthy Moscovites travel to an abandoned astrophysics complex, rumoured to have enough power to halt the process of aging.