Wild Bill Hickok (Bill Elliott) leads a wagon train of settlers from Kansas to Colorado. Along the way, they cross a group of Indians who don't want any more settlers on their land.
Tom Hilton and Stub Macey are heading to the Jergenson ranch to buy his cattle. But Jeckyl and Sheriff Slater control the cattle market forcing the ranchers to buy at their price and they intend to keep the newcomers out.