12-year-old Regan MacNeil begins to adapt an explicit new personality as strange events befall the local area of Georgetown. Her mother becomes torn between science and superstition in a desperate bid to save her daughter, and ultimately turns to her last hope: Father Damien Karras, a troubled priest who is struggling with his own faith.
In New York City, bright but naive New Englander Anne Welles becomes a secretary at a theatrical law firm, where she falls in love with attorney Lyon Burke. Anne befriends up-and-coming singer Neely O'Hara, whose dynamic talent threatens aging star Helen Lawson and beautiful but talentless actress Jennifer North. The women experience success and failure in love and work, leading to heartbreak, addiction and tragedy.
Bud Baxter is a minor clerk in a huge New York insurance company, until he discovers a quick way to climb the corporate ladder. He lends out his apartment to the executives as a place to take their mistresses. Although he often has to deal with the aftermath of their visits, one night he's left with a major problem to solve.
