Alice is young hearing-impaired girl who, after a supposed visitation from the Virgin Mary, is inexplicably able to hear, speak and heal the sick. As word spreads and people from near and far flock to witness her miracles, a disgraced journalist hoping to revive his career visits the small New England town to investigate. When terrifying events begin to happen all around, he starts to question if these phenomena are the works of the Virgin Mary or something much more sinister.
After the death of their father, widely celebrated theoretical physicist Driscoll Tarnow, the three Tarnow siblings (Leslie, Joey & Vyra) find themselves at a crossroads, splintering off into radically different directions in order to deal with the loss. Leslie recruits an ASU engineer to assist her in the construction of a fertilizer bomb, Joey falls in love while descending deeper into his addiction to Adderall, and Vyra becomes friends with a YouTube star with a very rare disease while working on a series of autobiographical paintings.
Maria, an American girl, and Ernst, her depraved German lover, must find their next hit of heroin on the streets of Berlin before their addiction threatens to tear their codependent relationship apart.