The Newton family live in their comfortable home, but there seems to something missing. This "hole" is filled by a small puppy, who walks into their home and their lives. Beethoven, as he is named, grows into a giant of a dog... a St Bernard. Doctor Varnick, the local vet has a secret and horrible sideline, which requires lots of dogs for experiments. Beethoven is on the bad doctor's list.
When secretive new neighbors move in next door, suburbanite Ray Peterson and his friends let their paranoia get the best of them as they start to suspect the newcomers of evildoings and commence an investigation. But it's hardly how Ray, who much prefers drinking beer, reading his newspaper and watching a ball game on the tube expected to spend his vacation.
