The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.
A sociopath prone to ultra-violent fantasies attempts to transform his reclusive lifestyle when the woman of his dreams moves-in next door - with horrific consequences.
A big city journalist is sent back to her small hometown to write a Fourth of July story and discovers the life and love she left behind are exactly what she's been missing.
Happy young married couple Paige and Leo are, well, happy. Then a car accident puts Paige into a life-threatening coma. Upon awakening she has lost the previous five years of memories, including those of her beloved Leo, her wedding, a confusing relationship with her parents, or the ending of her relationship with her ex-fiance. Despite these complications, Leo endeavors to win her heart again and rebuild their marriage.
As bass guitarist for a garage-rock band, Scott Pilgrim has never had trouble getting a girlfriend; usually, the problem is getting rid of them. But when Ramona Flowers skates into his heart, he finds she has the most troublesome baggage of all: an army of ex-boyfriends who will stop at nothing to eliminate him from her list of suitors.