Felix
Interrogado como sospechoso de asesinato, un respetable (pero borracho) ciudadano, Al Willis, ataca a sus interrogadores de la policía, es golpeado, y jura venganza contra ellos. A la noche siguiente, el teniente Parks es asesinado. Willis es el único sospechoso a los ojos del duro Jefe Conroy, quien lo persigue tenazmente a pesar de la falta de pruebas. El obsesivo Conroy es despedido por el uso de la fuerza, pero continúa hostigando a Willis, que huye a un pueblo en la frontera con México. Por supuesto, Conroy lo sigue, pero, ¿quién es el loco, Conroy o Willis?
Steve Bronson
A lawman infiltrates a gang of racketeers.
Bill Saunders
Although she is secretly married to a student, a young girl is forced to give up her baby rather than be thought of as an "unwed mother".
Dr. Watson
A District Attorney decides to go after a doctor who is targeting young women and talking them into having illegal abortions.
Surveyor
A crooked real estate manipulator sells worthless land on mortgage to flood refugees, then tries to profit by reselling the land to the state, committing murder in the process, as the Three Mesquiteers work to bring him and his gang to justice.
Gordon Tracy, before [Chs. 1, 12]
Dick Tracy's foe for this serial is the crime boss and Masked Mystery Villain The Spider/The Lame One and his Spider Ring. In the process of various crimes, including using his Flying wing and sound weapon to destroy the Bay Bridge in San Francisco and stealing an experimental "Speed Plane", the Spider captures Dick Tracy's brother, Gordon. The Spider's minion, Dr. Moloch, performs a brain operation on Gordon Tracy to turn him evil, making him secretly part of the Spider Ring and so turning brother against brother.
Marine
New York City cop Phil Donlon leaves the force to join the U.S. Olympic team. When he falls for a Marine colonel's daughter he gets kicked off the team. Joining the Marines to win the Colonel's approval many adventures follow.
Reporter
Ellery Queen solves a mystery involving a valuable stamp.