Felix
Questioned as a murder suspect, solid (but drunk) citizen Al Willis attacks his police questioners, is beaten, and swears vengeance against them. Next night, Lieut. Parks is murdered; Willis is the only suspect in the eyes of tough Chief Conroy, who pursues him doggedly despite lack of evidence. The obsessed Conroy is dismissed from the force, but continues to harass Willis, who flees to a sleazy town on the Mexican border. Of course, Conroy follows. But which is crazy, Conroy or Willis?
Steve Bronson
A lawman infiltrates a gang of racketeers.
Bill Saunders
Although she is secretly married to a student, a young girl is forced to give up her baby rather than be thought of as an "unwed mother".
Dr. Watson
A District Attorney decides to go after a doctor who is targeting young women and talking them into having illegal abortions.
Surveyor
A crooked real estate manipulator sells worthless land on mortgage to flood refugees, then tries to profit by reselling the land to the state, committing murder in the process, as the Three Mesquiteers work to bring him and his gang to justice.
Gordon Tracy, before [Chs. 1, 12]
Dick Tracy's foe for this serial is the crime boss and Masked Mystery Villain The Spider/The Lame One and his Spider Ring. In the process of various crimes, including using his Flying wing and sound weapon to destroy the Bay Bridge in San Francisco and stealing an experimental "Speed Plane", the Spider captures Dick Tracy's brother, Gordon. The Spider's minion, Dr. Moloch, performs a brain operation on Gordon Tracy to turn him evil, making him secretly part of the Spider Ring and so turning brother against brother.
Marine
New York City cop Phil Donlon leaves the force to join the U.S. Olympic team. When he falls for a Marine colonel's daughter he gets kicked off the team. Joining the Marines to win the Colonel's approval many adventures follow.
Reporter
Ellery Queen solves a mystery involving a valuable stamp.