Osamu Ino is a great doctor who is beloved in his rural village. His knowledge and dedication make an equally strong impression on his reluctant medical intern, Keisuke Soma. But, Soma and the villagers reconsider their opinion when they learn about a shameful incident from Dr. Ino's past. Now the once-respected doctor must account for his past actions.
Katsuhiro Ôtomo, famoso por sus filmes de animación (en especial "Akira"), dirige ahora una película de ciencia ficción, basada en un manga de Yuki Urushibara, que trata sobre Ginko, un joven maestro sanador que usa una extrañas forma de vida en sus curaciones. Los "mushi" son una suerte de espíritus parasitarios que flotan por todas partes sin ser vistos, y que afectan a los humanos de muy diversas maneras. Son algo así como "El fantasmal espíritu de la naturaleza que respira dentro de todo ser vivo... y muerto". Ginko, que puede verlos, se ha convertido en "mushishi", un experto en tales criaturas que ejerce como sanador.
A mysterious street-painter, Jouji, wanders aimlessly, homeless. Together with his homeless pals, he makes his living by selling his paintings on the street. His paintings, dynamically exploding on pieces of cardboard, catch the eyes of Kyoko, an art dealer. He can feel alive only if he keeps painting, but unable to find something to fill his void inside, he tries to drown himself in alcohol. Drawn to Jouji, Kyoko commissions him to paint for her. The two travel to a secluded mountain-side, and there Jouji becomes inspired both by the natural surroundings and Kyoko herself.
Kenichi is a half-Japanese, half-Chinese man of the underworld. You can sell him anything except children's organs. His domain is in Kabukicho, a gangland controlled by various Shanghai gangs intent on taking control. His former partner-in-crime, Fu-Chun, is rumored to have returned to Kabukicho, having fled years earlier after killing the number two of gangland boss, Yuan. Yuan wants to get even and attempts to do so by using Kenichi.
