El Transplante focuses on the story of "a mature couple" who "sees the need to renew their bodies to avoid being fired from their jobs", but who only have enough money for one of them. That limiting circumstance will force them to make decisions.
Oliver, a young film director, discovers on a porn Web site one night that the protagonist of one of the erotic videos is his younger half-sister Aurora. In the process of finding out what she was doing there, Oliver will become fascinated by his sister.
Tomás, who lives in Canada, travels to Madrid, Spain, to visit his old friend Julián. Both of them, accompanied by Truman, Julián's faithful dog, will share many surprising and emotional little moments, triggered by the hard situation Julián is going through, for just a few days.
A successful, attractive, intelligent and brilliant advertising executive is longing to finally find emotional stability in his life, and decides to propose to his girlfriend. After she refuses his proposal, his life takes a turn when a new young lady enters his life.
Angel, a young intelligent and kind, aims to be a police inspector. Rafael instead is an expeditious, forceful and arrogant policeman. Meanwhile, Miguel and Mateo are part of Group 7, a group of rogue cops ready to do anything to achieve their goals.