Detective Rita Rizzoli is accustomed to donning costumes and going undercover to nail crooks. But she'll be required to use all of her get-ups and more when a major cocaine ring is suspected of turning out a potent new strain of the drug, called "Fatal Beauty." With the help of her partner and a former bodyguard for a local cartel, Rita will do whatever it takes to find out who's dealing Fatal Beauty and stop them.
Nerdy high schooler Jerry Mitchell is assigned to write an article for the school paper about the infamous new delinquent transfer student, Buddy Revell. When Jerry accidentally invades Buddy's personal space and touches him, Buddy challenges Jerry to an afterschool fight in the parking lot, which Jerry tries to avoid at all costs.
With the help of student assistant Boris and stolen university equipment, Dr. Harry Wolper plans to clone his dead wife. But then he meets Meli, an egg donor for his experiment, and they fall in love. Faced with choosing between his deceased wife and Meli, Dr. Wolper sees his situation in a new light when Boris' own new love, Barbara, falls into a coma. Meanwhile, another professor tries shutting down the cloning project.