Manami helps out at her family's beauty salon and runs the unsuccessful "50% Theater Company." One night, after missing a call from Nao, her sister, Manami later discovers that Nao died that very night. After getting into a conflict with her mother, Manami and a friend set out for Tokyo in order to collect Nao's things. There, through encounters and reunions with various people, Manami finally comes to face with herself.
Dead bodies with eyeballs ruptured are continuously found. Their direct causes of death are heart attacks and they acted like they were possessed right before their deaths. Mizuki is a university student. Her friend dies in front of her. Meanwhile, Haruo’s younger brother dies. Mizuki and Haruo begin to investigate together. They learn that Eiko holds a key to the mystery. Soon, Eiko's eyeballs rupture and she dies by a heart attack. Before she dies, she mentions the word "Shirai-san.”
The story of the original manga writer Rieko Saibara is depicted by her alter ego Natsumi Takahara who revisits where she was raised and recalls her childhood and how everything turned out.
When the Earth's ecosystem is disrupted due to global warming, a plethora of prehistoric sea monsters wage war on Japan. Led by the powerful Raiga, the monsters ravage the city of Asakusa.
Set in World War II, the film depicts the story of the real-life Japanese battleship, the Yamato, which is confronted in the Pacific Ocean by giant monsters, including the most fearsome of them all, Reigo.