The TARDIS arrives in 2070 on the Moon, where a weather control station under the command of a man named Hobson is in the grip of a plague epidemic — in reality the result of an alien poison planted by the Cybermen. Jamie is knocked unconscious and lapses into a delirium, leaving the Second Doctor, Ben, and Polly to fight off a massive Cyberman attack.
Whilst vacationing in the Carpathian Mountain, two couples stumble across the remains of Count Dracula's castle. The Count's trusted servant kills one of the men, suspending the body over the Count's ashes so that the blood drips from the corpse and saturates the blackened remains. The ritual is completed, the Count revived and his attentions focus on the dead man's wife who is to become his partner; devoted to an existence of depravity and evil.
The lost city of Kuma is ruled by the cruel, arrogant, beautiful queen, Ayesha, gifted with eternal life. She lures Leo Vincey into her world, seeing in him the reincarnation of the lover she long ago murdered in a fit of violent jealousy. Against all advice Leo is determined to stay and Ayesha persuades him to bathe in the flame of eternal youth... with disastrous consequences.