Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.
Spenser is hired out by Hugh Dixon to track down the killers of his wife and daughters. He and Hawk are drawn into a huge plot involving assassination attempts on African leader Winston Boyko by some racist terrorist named Paul.
Days away from her wedding to Steve Austin, Jaime Sommers experiences a mysterious breakdown of her Bionic limbs. With her physical fate unknown, Jaime calls off the wedding. Her condition quickly deteriorates, and Dr. Rudy Wells races to find the cause behind the breakdown. Meanwhile, in the Bahamas, terrorist Miles Kendrick takes control of the American Embassy and threatens the launch of a nuclear missile. Steve and OSI operative Kimberly Harmon head to the Bahamas to stop Kendrick, but in the midst of the mission Steve is suddenly stricken with the same computer virus that is destroying Jaime.
Kim Jameson is a university professor while Kate Jameson - also known as Dominique, Kim’s twin sister - is a troubled model working in Paris. Kate is a drunk, in desperate need of rehabilitation. Kim checks her twin sister into a rehab center, agreeing to fill in for Dominique during her absence, but by doing so takes on more than she bargained for.