Três histórias trágicas se cruzam: a do pesquisador Tyrone Brower, contratado por uma empresa farmacêutica, a da arquiteta Claire Reimann, uma viciada em recuperação, e a do agente Jake Kelly, infiltrado em dois grandes cartéis de drogas. Todas afetadas pela epidemia de opioides nos EUA.
Numa villa italiana, arruinada após o fim da Segunda Guerra Mundial, uma enfermeira militar do exército canadiano cuida de um aviador britânico desconhecido, que teve queimaduras generalizadas quando o seu avião foi abatido. Assim, aos poucos, ele começa a narrar o grande envolvimento que teve com a mulher do seu melhor amigo e de como este amor, fortemente correspondido, acabou da pior maneira.
Spenser is hired out by Hugh Dixon to track down the killers of his wife and daughters. He and Hawk are drawn into a huge plot involving assassination attempts on African leader Winston Boyko by some racist terrorist named Paul.
Days away from her wedding to Steve Austin, Jaime Sommers experiences a mysterious breakdown of her Bionic limbs. With her physical fate unknown, Jaime calls off the wedding. Her condition quickly deteriorates, and Dr. Rudy Wells races to find the cause behind the breakdown. Meanwhile, in the Bahamas, terrorist Miles Kendrick takes control of the American Embassy and threatens the launch of a nuclear missile. Steve and OSI operative Kimberly Harmon head to the Bahamas to stop Kendrick, but in the midst of the mission Steve is suddenly stricken with the same computer virus that is destroying Jaime.
Kim Jameson is a university professor while Kate Jameson - also known as Dominique, Kim’s twin sister - is a troubled model working in Paris. Kate is a drunk, in desperate need of rehabilitation. Kim checks her twin sister into a rehab center, agreeing to fill in for Dominique during her absence, but by doing so takes on more than she bargained for.
