Following a childhood tragedy, Dewey Cox follows a long and winding road to music stardom. Dewey perseveres through changing musical styles, an addiction to nearly every drug known and bouts of uncontrollable rage.
On its way back to Earth, the space shuttle Nautilus passes through a cloud of alien spores causing its sole occupant, astronaut Steve Thomas to transform into a blood-thirsty monster. The shuttle crashes into a swampy region of central Florida, creating a situation which threatens contagion and/or death to all who encounter the shuttle or its mutated pilot.
