Marco is married to a gorgeous woman, has a child and a great job. Everything seems perfect, at least until his wife of 25 years announces that she has another man and wants a separation. Marco is forced to leave home.
Bruno Fioretti, known as "Mandrake", is an inveterate gambler who never misses a day at the horse racing track in Rome. He is doubly unlucky: he bets too much on one horse, and his wife is sleeping with his best friend because Mandrake is always at the track. Penniless and cuckolded, Mandrake decides to make one last bet.
Um adolescente chamado Josuke Higashikata descobre que possui habilidades sobrenaturais; herdadas de uma linhagem amaldiçoada e bizarra que abrange gerações. Quando ele descobre que alguém dentro de sua cidade natal está concedendo a outros poderes semelhantes, Josuke inicia uma aventura para desvendar quem é esta misteriosa ameaça.
