Entirely made in California, the film brings together 30 American and European actors in an epic which crosses the mythical territories of that cinematic land from Zabriskie Point to Mulholland Drive. California is revisited through the movie memories incarnated by the very presence of famous actors and actresses. "The American Tetralogy" is a way of staging reality which questions the fictional nature of the movies.
Joe Sujo (David Spade) é um faxineiro com um penteado antiquado, que sempre usa as mesmas calças jeans surradas e tem um sonho: reencontrar seus pais, que não vê desde que se perdeu deles aos 8 anos de idade, em uma visita ao Grand Canyon. E para realizar este sonho ele resolve partir numa viagem de carro rumo a Los Angeles, onde se torna astro do programa de rádio "As aventuras de Joe Sujo", onde pode contar as histórias de sua vida e acaba se tornando uma figura conhecida na cidade.
A struggling freelance writer, while investigating the transvestite night life, stumbles across a serial killer in action. The two then strike up a bizarre partnership to document the killer's motives and handiwork as a possessed detective struggling with his own personal demons tries to solve the crimes.
A paroled short order cook and a waitress go on the run with a bag of diamonds that accidentally falls into their possession, prompting two warring gangs to come after them.
A depressed housewife whose husband is having an affair contemplates suicide, but changes her mind when she faces death by a killer hired to do her in.
