A modelo americana Celine é sequestrada em Milão durante a Semana da Moda. O autor é um serial killer conhecido como Giallo e que faz suas vítimas passarem por um verdadeiro calvário. Linda, irmã de Celine, deixa o assunto nas mãos do inspetor Enzo Lavia, que deverá encontrar a garota antes que ela sofra o terrível final das vítimas anteriores.
Italy, at the end of the 21st century. Quinto, a gentle, naive man on his quest to find the fabled 'City in the Sky' arrives at a dilapidated family-owned hotel run by transsexual Dora and her drug addict son. Locked in one of the rooms is Ai, a malfunctioning android prostitute, waiting to be deactivated. By error at check-in, Quinto meets her.
When a producer refuses to cut Massimo and his band a record unless they hire an "ethnic" singer to spice up the act, he tries to seduce Jing, a Chinese girl with a beautiful voice disinterested in both him and rock, to get her on board. She pretends to cave in in order to escape an arranged marriage, but in the weeks preceding the concert the two begin to grow closer, complicating the secretly fake nature of their relationship.
A teenage girl spending the night at the place of a boy she likes finds herself targeted by a mysterious serial killer who may be the very boy she is with.
