Billy Van is a dangerous and perfidious outlaw who kidnapped a wealthy woman and the wife of Hamilton Monroe for ransom. However, Hamilton, makes an offer to free Billy's partner Jesson from prison. But it was Billy Van who double-crossed Jesson and put him in the prison. Now it's up to Jesson to find Billy and bring the kidnapped Maria back to get his freedom. Jesson teams up with a professional guide Sandy, Dirty Bob and a sharpshooter Little Swede, to find Billy, and goes on to achieve double purpose goal.
No primeiro filme havia Michael J. Fox trasformando-se em lobo no colégio. Neste Fox sai de cena e aparece outro rapaz, agora na faculdade, que vê um monte de pêlos crescerem em seu corpo.
