Spike Lee conta a história de quatro veteranos de guerra afro-americanos que voltam ao Vietnã à procura dos restos mortais de seu comandante e de um tesouro enterrado.
"I learn that Chris McIntyre served in Vietnam and that "21 and a Wakeup," set in an Army hospital in the waning days of the war, is based on events that he experienced and heard about." - Roger Ebert