Em um futuro próximo, um homem (David Thewlis) em missão militar sofre um acidente no seu avião e, depois de vários dias, é resgatado por um cientista que o leva a uma remota ilha, onde um famoso geneticista (Marlon Brando), vencedor do prêmio Nobel, faz experiências com DNA e tenta criar uma raça perfeita, transformando animais selvagens em seres humanos. Porém, esta estranha mutação vai criar situações imprevisíveis.
General Romero, leader of a small Latin American country, is showing the UN how he's taking care of his country's drug problems by publicly burning crops of marijuana. As soon as the inspectors leave, however, Romero quickly returns to business, producing and shipping the illegal crop. When his right-hand man is convinced by a crusading reporter to turn away from his life of crime and help bring his boss to justice, Romero vows to stop at nothing to prevent this traitor from talking.
A maniac butchers a fashion model on a Caribbean island and leaves the body to be eaten by rats. The model's sister suspects something isn't quite right with the police investagation and decides to go snooping on her own. With her friend, Fred, their investagations lead them to an unknown part of the island where they discover a monstrosity of a rat like man. The creature is killed by Fred, but the true horror of it's nature is just beginning...
